What are the best 18+ nightclubs / lounges in San Francisco. Taking my sister for her 19th b-day?

We will be a group of females ages 18, 19 , 21, 25, 27. Looking for fun things to do over the upcoming holiday weekend. Nightclubs 18+ (if there are any that the older girls will have fun at as well), great restaurants, museums, shopping. Maybe even good day excursions.